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Becker, Y. (1995). "Computer
simulations to predict the availability of peptides
with known HLA class I motifs generated by proteolysis
of dengue fever virus (DFV) type 1 structural and nonstructural
proteins in infected cells." Virus Genes 10: 195-203.
Y Becker, Hebrew Univ Jerusalem, Fac Med, Inst Microbiol,
Dept Molec Virol, IL-91010 Jerusalem, Israel Cytotoxic
T cells that recognize dengue fever viral (DFV) peptides
were reported. To predict the cleavage pattern of DFV
proteins by cytoplasmic proteasomes into nonapeptides
with motifs fitting known HLA class I molecules, the
computer program ''Findpatterns'' was used. In this
study the combined amino acid motifs for proteolytic
cleavages and the HLA class I haplotype- restricted
peptides were analyzed. It was noted that putative peptides
with motifs of HLA A2 and A68 were abundant compared
with nonapeptides with motifs HLA A24, B8, B35, and
B53. The possible interpretation of the computer analysis
in explaining the cellular immune response in endogenous
populations of endemic DF is discussed
Bellanti, J. A., R. T. A. Bourke,
et al. (1966). "Report of dengue vaccine trial
in the Caribbean, 1963: a collaborative study."
Bull.World Health Organ. 35: 93.
Berard, H. and M. Laille (1990). "[40
cases of dengue (serotype 3) occurring in a military
camp during an epidemic in New Caledonia (1989). The
value of vector control] A propos de 40 cas de dengue
(serotype 3) survenus dans un camp militaire lors de
l'epidemie de Nouvelle-Caledonie (1989). Interet de
la lutte antivectorielle." Med.Trop.(Mars). 50:
423-428.
An epidemic of dengue occurred at the beginning of 1989
in New Caledonia. About 18 p.c. of the population was
stricken (25,000 to 30,000 estimated clinical cases).
The military camp of Plum was stricken too, but a prompt
vector control was established. 8.6 p.c. of the strength
was affected by classical dengue without severe hemorrhagic
manifestations. Such prevalence is lower than the one
rated in the civil population, demonstrating the major
importance of vector control to limit spreading of such
an epidemic as a tetravalent vaccine is not yet available.
Bergstrom, T., E. Trybala, et al.
(1997). "Heparan sulfate and viral tropism [letter]."
Nat.Med. 3(11): 1177.
Berrios, V., I. Kurane, et al. (1996).
"Immunomodulatory effects of IL-7 on dengue virus-specific
cytotoxic CD4+ T cell clones." Immunol.Invest.
25(3): 231-40.
Lymphokines play an important role in immune responses
to viruses by modulating functions of T lymphocytes.
We examined the effects of interleukin-7 (IL-7) on the
growth and cytotoxic activity of dengue virus-specific,
CD4+ human cytotoxic T lymphocyte (CTL) clones. We then
compared the effects of IL-7 with those of interleukin-2
(IL-2). The CD4+CTL clones were stimulated with dengue
antigen or monoclonal antibody to CD3 in the presence
of IL-7 or IL-2. IL-7 induced the growth of CD4+CTL
clones and maintained the antigen-specific cytotoxic
activity without inducing antigen-non-specific cytotoxic
activity. The levels of the growth and cytotoxic activity
induced by IL-7 were similar to those induced by IL-2.
IL-7 and T-cell growth factor had an additive effect
on the growth of CD4+CTL clones. These results suggest
that IL-7 may play an important role in CD4+ T cell
immune responses to viruses and that IL-7 is a
 
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